Cish attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function

Lung-specific expression of the SOCS family member Cish is driven by steady-state GM-CSF signaling and shapes alveolar macrophage identity and homeostatic function. Gene expression in alveolar macrophages from WT and Cish-/- mice细胞因子信号抑制因子（Suppressor of Cytokine Signaling, SOCS）家族成员Cish的肺特异性表达受稳态粒细胞-巨噬细胞集落刺激因子（Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF）信号通路调控，并可塑造肺泡巨噬细胞的细胞身份与稳态功能。本数据集涵盖野生型（Wild Type, WT）及Cish基因敲除（Cish-/-）小鼠肺泡巨噬细胞的基因表达谱数据。