Comparative analysis of gene expression in the skin of WT and LynDeltaN mice. Mus musculus

The caspase cleaved form of the tyrosine kinase Lyn (LynDeltaN) mediates a psoriasis-like inflammatory syndrome in mice. To gain insights into the molecular mechanism of LynDeltaN in the control of this infllammatory process, we performed the pangenomic profile of WT and LynDN skin from 5 day-old mice just before the entire inflammatory syndrom takes place. Overall design: Skin samples from 3 wt and 3 LynDN transgenic mice were compared in a dye-swap experiment.