NELFCD: A Crucial Factor in Uveal Melanoma Cell Proliferation and Tumorigenesis

Uveal melanoma is the most common intraocular malignant tumour in adults.Posterior uveal melanoma is highly likely to metastasise to the liver (89%), lungs (29%), bone (17%), skin and subcutaneous tissues (12%), and lymph nodes (11%) and has an extremely high mortality rate.Due to the unclear pathogenesis, there is still no effective treatment for uveal melanoma other than surgery.Thus, it is crucial to investigate the mechanisms of carcinogenesis and proliferation of uveal melanoma.Recent evidence suggests that biomolecular condensates,membrane-free cellular compartments formed by liquid-liquid phase separation (LLPS), plays crucial roles in physiological and tumorigenic processes.The aim of this study was to investigate the role of LLPS in the development of uveal melanoma in order to explore potential therapeutic targets for UM. Overall design: The experiment was set up with three groups of control cells and three groups of cells knocking down NELFCD.