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A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

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资源简介:
Prostaglandin E2 (PGE2) modulates macrophage activation during homeostasis and disease, but the underlying mechanisms remain incompletely characterized. Cilenti, Barbiera, et al. reveal that PGE2 suppresses inflammatory gene expression by targeting a set of inflammatory gene enhancers marked by MEF2A, a critical regulator of type I interferon induction. DOI: https://doi.org/10.1016/j.immuni.2021.05.016 Raw and analyzed RNA-Seq data: This paper, ArrayExpress: E-MATB-9275 Raw and analyzed scRNA-Seq data: This paper, ArrayExpress: E-MATB-9253 Raw and analyzed ChIP-Seq data: This paper, ArrayExpress: E-MATB-9254 Raw and analyzed ATAC-Seq data: This paper, ArrayExpress: E-MATB-9252
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2022-02-11
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