FLUID SHEAR STRESS-INDUCED MECHANOTRANSDUCTION IN MYOBLASTS: DOES IT DEPEND ON GLYCOCALYX?

Muscle stem cells (MuSCs) are requisite for
skeletal muscle regeneration and homeostasis. Mechanically loaded MuSCs within
their native niche undergo tensile and shear deformations, but how MuSCs sense
mechanical stimuli and translate these into biochemical signals regulating
function and fate is still poorly understood. The glycocalyx is known to affect
the response of endothelial cells, bone cells, and myotubes to fluid shear
stress (FSS), but whether it plays a role in the mechanoresponse of MuSCs is
unknown. The data published here is the research output on the role of glycocalyx in mechanotransduction.