Chemical Genetics of TOR Identifies an SCF Family E3 Ubiquitin Ligase Inhibitor
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22272
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资源简介：
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyper-activation of the mTOR pathway in human cancers, novel strategies to enhance TOR pathway inhibition are highly desirable. We used a yeast-based high-throughput chemical genetic screen to identify small-molecule enhancers of rapamycin (SMERs) and used whole genome expression analysis to identify their mechanisms of action. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
创建时间：
2017-02-21
