Decoding G Protein-Coupled Receptor Signalling Fingerprints to Identify Novel Therapeutic Targets for Cardiac Fibrosis Treatment

Cardiac fibrosis, a hallmark feature of heart failure, presents a daunting challenge in cardiovascular medicine. Exploring G protein-coupled receptors (GPCRs) holds promise for innovative therapeutic interventions. GPCRs, abundant in cardiac fibroblasts, regulate key fibrotic pathways. Targeting these receptors offers a strategic approach to modulate fibrotic processes, potentially halting disease progression. This thesis focused on identifying therapeutic targets to pave way for effective therapies to treat cardiac fibrosis. By deciphering the intricate GPCR signaling cascades, this thesis has identified novel targets that would be further evaluated for potential harnessing for cardiac fibrosis treatment in heart failure.