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Integrated Clinical and microRNA Signatures for Predicting Altitude-Related Hypertension

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP656592
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Methods We established a high-altitude cohort including normotensive entrants (N), altitude-related hypertension (ARH), and long-term essential high-altitude hypertension (EHH). Clinical indicators, biochemical markers, and cytokines were analyzed using the compareGroups R package. Differential miRNA expression determined by log2FC > 1.5 and adjusted P < 0.05. Functional enrichment analyses were conducted via clusterProfiler, and PPI networks were constructed using STRING and Cytoscape. Diagnostic performance was assessed using ROC analysis.
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2025-12-20
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