TP53 binds ZNF385A

ZNF385A (HZF) forms a complex with TP53 (p53), interacting with the DNA binding domain of TP53. The complex of TP53 and ZNF385A associates with p53 response elements of cell cycle arrest genes, such as CDKN1A (p21) and stimulates their transcription. Under prolonged stress, ZNF385A undergoes ubiquitination and proteasome-mediated degradation, which coincides with expression of TP53-regulated pro-apoptotic genes (Das et al. 2007).

ZNF385A（即HZF）与TP53（p53）形成复合物，并与TP53的DNA结合域相互作用。该复合物与细胞周期停滞基因（如CDKN1A（p21））的p53响应元件相结合，并刺激其转录。在长期的应激状态下，ZNF385A经历泛素化和由蛋白酶体介导的降解，这与TP53调控的促凋亡基因的表达相一致（参见Das等，2007年）。