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Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

ChEBI2012-12-06 更新2026-07-21 收录

合成致死筛选

黑色素瘤靶向治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-39192 数据链接链接失效反馈

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Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

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2012-12-06

合成致死筛选

PI3K靶向治疗

Gastric cancer is the third leading cause of cancer death, responsible for over 1 million new cases per year. The Cancer Genome Atlas (TCGA) identified that EBV infects nearly 10% of all gastric carci

NIAID Data Ecosystem30

The NEMO (NF-KB Essential Modulator) Binding Domain (NBD) peptide induces apoptosis in several melan. Homo sapiens

黑色素瘤靶向治疗

NF-κB信号通路调控

The transcription factor NF-kB is an important regulator of genes involved in inflammation and cell proliferation. Several studies previously showed that NF-kB transcription factor was constitutively

NIAID Data Ecosystem10

Additional file 3 of Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors

癌症基因治疗

合成致死筛选

Additional file 3: Table S2. Guide-RNA target sequences for the validated synthetic viable genes.

NIAID Data Ecosystem10

Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear Accumulation of TP53, Phosphorylated MAPK and Apoptosis in Human Melanoma Cells

黑色素瘤靶向治疗

核输出蛋白抑制剂

XPO1/CRM1 is a key nuclear exporter protein that mediates translocation of numerous cellular regulatory proteins. We investigated whether XPO1 is a potential therapeutic target in melanoma using novel

NIAID Data Ecosystem10

Supplementary Tables S1-S3 from BRAF Gene Copy Number and Mutant Allele Frequency Correlate with Time to Progression in Metastatic Melanoma Patients Treated with MAPK Inhibitors

肿瘤生物标志物

黑色素瘤靶向治疗

Table S1. Nucleotidic sequences of primers and probes used in the qPCR analyses. Table S2. Detailed description of BRAF copy number (CN) and mutant-allele specific quantification results. Table S3. An

Figshare2018-06-01 更新10

Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

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