Metadata record for the manuscript: Establishment and characterization of immortalized human breast cancer cell lines from breast cancer patient-derived xenografts (PDX)

<b>Summary</b><br> This metadata record provides details of the data supporting the claims of the related manuscript: “Establishment and characterization of immortalized human breast cancer cell lines from breast cancer patient-derived xenografts (PDX)”. The related study utilised breast cancer PDX from the Mayo Breast Cancer Genome Guided Therapy Study (BEAUTY) to establish two immortalised, genomically unique breast cancer cell lines. Type of data: whole exome sequencing Subject of data: <i>Mus musculus, </i>breast cancer patient-derived xenografts and matched PDX-derived immortalised human breast cancer cell lines Population characteristics: NSG NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (Stock No: 005557) female mice <b>Data access</b> Whole exome sequencing for each PDX and PDX-derived cell line are openly available in the <i>Sequence Read Archive </i>via accession https://identifiers.org/ncbi/insdc.sra:SRP274166 (BioProject accession: PRJNA649579). The following data are openly available as part of this data record: the histology images, in the zip file ‘Fig4_Histology.zip’; additional data supporting the figures and supplementary figures of the related article, in the Excel spreadsheet ‘Extended_Text_and_Tables.xlsx’. Additionally, Supplementary Tables 1-4 and the raw Western blot images are included with this data record, as well as with the related article. <b>Corresponding author(s) for this study</b> Liewei Wang M.D., Ph.D., Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905 USA. Tel: [phone]; Fax: [phone]; Email: [e-mail] <br> <b>Study approval </b> All protocols for animal studies have been approved by the IACUC committee of Mayo Clinic.