Transcriptomics profiling at norvancomycin producing strains

Norvancomycin has been widely used in clinic to against Gram-positive bacteria, especially MRSA (Methicillin-resistant Staphylococcus aureus) and MRSE (methicillin-resistant Staphylococcus epidermidis) in China. Amycolatopsis orientalis NCPC 2-48, a high yield strain derived from Amycolatopsis orientalis CPCC200066, has been used for industrial large-scale production of the vital antibiotic norvancomycin by the North China Pharmaceutical Company. Here we sequenced and compared the transcriptomes of CPCC200066 and NCPC 2-48, to identify high yield mechanism potentially involved in the norvancomycin biosynthetic pathway.