OPTIMIZATION OF EARLY DIAGNOSIS AND PREVENTION OF INTRAHEPATIC CHOLESTASIS IN PREGNANT WOMEN (LITERATURE REVIEW)

A rare class of severe inflammatory skin illnesses that are itchy and specifically linked to pregnancy and/or the first few days after giving birth is called intrahepatic cholestasis of pregnancy. Pregnant women have a high prevalence of cutaneous AD and an annual increase in incidence, similar to the overall population. The most recent data indicates that between 5 and 20% of pregnant women have dermatosis; in industrial cities and megalopolises, this percentage is significantly greater. Since only a few pregnant dermatoses have conclusive diagnostic tests, clinical diagnosis based on morphological criteria is still crucial. All of these conditions, however, share a common symptom: intense skin itching, which considerably lowers the pregnant woman's quality of life. One of the most urgent problems in modern medicine is the problem of allergic dermatoses, which is closely linked to polyvalent sensitization of the population, the extensive use of polymeric materials in production and daily life, the unfavorable environmental conditions on the planet, and high solar activity that promotes their growth [Williams N.S., Strachan D.P., May R.J., Werfel T., Kapp A., 2015, Roy Patterson, Leslie K., 2013, Eisen M.A., Kaur S.L., Silm H.A., 2016].