首页/数据集/The multikinase inhibitor Sorafenib targets mitochondria and synergizes with glycolysis blockade for cancer cell killing.

The multikinase inhibitor Sorafenib targets mitochondria and synergizes with glycolysis blockade for cancer cell killing.

ChEBI2015-02-04 更新2026-07-21 收录

肿瘤药理学

癌症代谢治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-43053 数据链接链接失效反馈

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The multikinase inhibitor Sorafenib targets mitochondria and synergizes with glycolysis blockade for cancer cell killing.

应用场景：

创建时间：

2015-02-04

癌症代谢治疗

转录调控机制

BACKGROUND: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways and ATP levels sufficient to support translation. Crosstalk between th

NIAID Data Ecosystem70

Inhibition of A549 cell viability by trypacidin.

肿瘤药理学

毒性评估

A549 cells were exposed for 1 h and 2 h with 10 µM and 50 µM trypacidin, then the medium containing trypacidin was replaced by fresh medium and cell viability was measured 24 h later using MTT assay.

NIAID Data Ecosystem50

Genome scale metabolic models as tools for drug design and personalized medicine

药物靶点预测

癌症代谢治疗

In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human metabolites (obtained using their KEGG indexes

Figshare2018-01-06 更新30

Main mechanism of action of cisplatin, gemcitabine, vinorelbine and docetaxel.

药物作用机制

肿瘤药理学

Main mechanism of action of cisplatin, gemcitabine, vinorelbine and docetaxel.

NIAID Data Ecosystem60

Inhibiting MYC-regulated Glutaminase Metabolic Axis is an Effective Synthetic Lethal Approach for Treating Chemoresistant Cancers. Inhibiting MYC-regulated Glutaminase Metabolic Axis is an Effective Synthetic Lethal Approach for Treating Chemoresistant Cancers

癌症代谢治疗

合成致死治疗

Amplification and expression of the MYC oncogene in tumor cells, including ovarian cancer cells correlates with poor responses to chemotherapy. As MYC is not directly targetable, we have analyzed mole

NIAID Data Ecosystem50

The multikinase inhibitor Sorafenib targets mitochondria and synergizes with glycolysis blockade for cancer cell killing.

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