Liposome nanoparticles loaded with TDP-43 aggregation inhibitor regulate the activation of cGAS STING inflammatory pathway, reduce astrocyte astrocyte crosstalk, and alleviate neuropathic pain

Neuropathic pain (NP) is a complex and difficult to treat chronic pain state, mainly caused by the crosstalk of microglia and astrocytes. The aim of this study is to prepare liposomes loaded with TDP-43 aggregation inhibitors and explore their mechanism of action in NP, in order to provide new ideas and potential therapeutic strategies for the treatment of NP