Role of DPYSL2A in KLF4-mediated monocytic differentiation in AML cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101751
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To compare the global gene expressions in between KLF4- and DPYSL2A-expressed AML cells, we conducted gene expression arrays in THP-1 cells lentivirally-transduced with doxycycline-inducible KLF4 or DPYSL2A. We identified the pivotal role of KLF4-DPYSL2A axis in differentiating AML cells, which could be theraputically-tageted in conventional therapy-resistant AML patients. THP-1 cells were transduced with lentivirus encoding KLF4 or DPYSL2A under doxycycline responsive promoters. Cells were treated with 3 μM doxyxicline for 48 hours to induce gene expressions.
创建时间：
2021-07-25
