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Single-nucleus transcriptomics and chromatin accessibility of cell type-specific contributions to the epileptogenic cortex of focal cortical dysplasia type IIIa

NIAID Data Ecosystem2026-05-02 收录

癫痫病理机制

单细胞神经组学

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE266308 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2024-10-31

单细胞神经组学

海马体细胞异质性

Subiculum pyramidal cells constitute a prominent output neuron class of the hippocampus. Here, we examined diversity in this cell type using single-cell RNA-seq. Examination of subiculum pyramidal cel

NIAID Data Ecosystem100

Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [KA and APOE]

癫痫病理机制

星形胶质细胞代谢

Abnormal lipid accumulation have been reported in patients with temporal lobe epilepsy (TLE) by in vivo magnetic resonance imaging (MRI). However, the role of astrocytes in the regulation of neuronal

NIAID Data Ecosystem50

Table2_Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy.DOCX

癫痫病理机制

胶质疤痕形成

Glial scars have been observed following stab lesions in the spinal cord and brain but not observed and characterized in chemoconvulsant-induced epilepsy models. Epilepsy is a disorder characterized b

NIAID Data Ecosystem30

Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]. Lipid-accumulated reactive astrocytes promote seizure activity in epilepsy [mouse]

癫痫病理机制

星形胶质细胞代谢

Abnormal lipid accumulation have been reported in patients with temporal lobe epilepsy (TLE) by in vivo magnetic resonance imaging (MRI). However, the role of astrocytes in the regulation of neuronal

NIAID Data Ecosystem50

Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis

干细胞神经分化建模

单细胞神经组学

We applied single nuclei and single cell transcriptomics methods to model interneuron development with interneurons derived from human PSCs. We find that PSC-derived interneurons capture stages of dev

NIAID Data Ecosystem40

Single-nucleus transcriptomics and chromatin accessibility of cell type-specific contributions to the epileptogenic cortex of focal cortical dysplasia type IIIa

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