Spatial Transcriptomics Identifies Immune-Stromal Niches Associated with Cancer in Adult Dermatomyositis

This dataset contains two primary R data objects from our study on adult-onset dermatomyositis (DM) and cutaneous lupus erythematosus (CLE): 5k_19samples.RDS: Spatial Seurat object containing high-resolution spatial transcriptomics data (Xenium Prime 5K, 10X Genomics) from 19 skin biopsies including: 12 DM lesional samples 4 CLE lesional samples 3 healthy control samples flex_44samples.RDS: Seurat object containing single-cell RNA sequencing data (Chromium Single Cell Gene Expression Flex) from 44 skin biopsies including: 22 DM patients (lesional) 9 CLE patients (lesional) 8 non-lesional samples from a subset of patients 6 healthy controls