Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We show that the epididymal white adipose tissue harbors 4 subpopulations of macrophages (VAM1, VAM2, PreVAM and DPs), 2 subpopulations of Dendritic Cells (CD11B+CD103- and CD11B-CD103+) and monocytes. VAMs display a gene signature enriched in pathways related to anti-inflammatory/ detoxifying and repair processes. Our gene expression work shows no evidence of an M2 to a Classically Activated/M1 shift during diet-induced obesity (DIO). Gene expression of VAMs or DP macrophages cannot be defined as M1 or M1-like. Our data are more compatible with the category of âMetabolically-activatedâ macrophages (MMe)
提供机构：
New York University Langone Medical Center
创建时间：
2022-02-20
