Distribution of hotspots and defective alleles in different regions of the virtual chromosomes after 3 million MC steps.

Positions 1–783 and 1819–2047 are regions on the chromosome where the detrended cumulative plot for “allowed” positions (double hotspots) shows the increasing trend whereas the trend is decreasing in the region 784–1818 (see Fig. 4A). Since the fraction of homozygous defective loci is of the order of 0.0003, almost all defective alleles shown in the table are at the heterozygous positions. Double hotspots correspond to positions where recombination can occur, whereas at single hotspot positions recombination cannot happen.