USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2

USP37 deubiquitinates Lys-11-linked polyubiquitin chains from cyclin-A (CCNA1 and CCNA2), which opposes the Lys-11-linked polyubiquitination mediated by the anaphase-promoting complex (APC/C) during G1/S transition, thereby promoting S phase entry. Phosphorylation by CDK2 at Ser-628 during G1/S phase maximizes USP37 deubiquitinase activity (Huang et al. 2011).

USP37通过去泛素化由CCNA1和CCNA2编码的细胞周期蛋白A（cyclin-A）上与赖氨酸-11连接的多泛素链，此过程与有丝分裂促进复合物（APC/C）介导的赖氨酸-11连接的多泛素化相拮抗，从而促进S期进入。在G1/S期，CDK2在Ser-628位点上的磷酸化作用最大化了USP37的去泛素化酶活性（黄等，2011年）。