Crystal structure of SHP2 in complex with JAB-3186
收藏Protein Data Bank Japan2024-09-04 更新2026-06-30 收录
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Crystal structure of SHP2 in complex with JAB-3186 Descriptor: (5~{S})-1'-[6-azanyl-5-(2-azanyl-3-chloranyl-pyridin-4-yl)sulfanyl-pyrazin-2-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4'-piperidine]-5-amine, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Ma, C, Gao, P, Kang, D, Han, H, Sun, X, Zhang, W, Qian, D, Wang, Y, Long, W. Deposit date: 2023-10-27 Release date: 2024-08-14 Last modified: 2024-09-04 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment. J.Med.Chem., 67, 2024
创建时间：
2023-10-27
