Oligosaccharyltransferase is involved in targeting to ER-associated degradation

The majority of secretory proteins undergo N-glycosylation, a process catalyzed by oligosaccharyltransferase (OST), a membrane-bound protein complex that associates with the translocation channels within the endoplasmic reticulum (ER). Proteins failing quality control undergo ER-associated degradation (ERAD) by retrotranslocation to cytosolic proteasomes. Using a misfolded protein bait and SILAC proteomics, we unexpectedly identified several OST subunits among top hits. For further details, Please refer to the publication "Oligosaccharyltransferase is involved in targeting to ER-associated degradation" by Marina Shenkman et al..