Supplementary Material for: Risk Factors for Acute Kidney Injury and Chronic Kidney Disease following Allogeneic Hematopoietic Stem Cell Transplantation for Hematopoietic Malignancies

<b><i>Background:</i></b> Acute kidney injury (AKI) and chronic kidney disease (CKD) are considered common complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). <b><i>Objectives and Method:</i></b> In this study, 114 patients who had undergone allo-HSCT were retrospectively analyzed to investigate the risk factors for onset of posttransplant AKI and CKD as defined by the new Kidney Disease Improving Global Outcomes criteria. <b><i>Results:</i></b> Seventy-four patients (64.9%) developed AKI and 25 (21.9%) developed CKD. The multivariate analysis showed that the risk factors for developing stage 1 or higher AKI were age ≥46 years at the time of transplant (<i>p</i> = 0.001) and use of ≥3 nephrotoxic drugs (<i>p</i> = 0.036). For CKD, the associated risk factors were disease status other than complete remission at the time of transplantation (<i>p</i> = 0.018) and onset of AKI after transplant (<i>p</i> = 0.035). The 5-year overall survival (OS) was significantly reduced by development of AKI (<i>p</i> &lt; 0.001), but not CKD. Posttransplant AKI significantly increased the 5-year nonrelapse mortality (<i>p</i> &lt; 0.001), whereas posttransplant CKD showed an increasing tendency, but the difference was not significant. <b><i>Conclusions:</i></b> Posttransplant AKI impacts OS, significantly increases the risk of CKD, and is significantly associated with disseminated intravascular coagulation and use of ˃3 nephrotoxic drugs.