Dimerization of Tie2/Ang1 complex

Receptor tyrosine kinase activation and signaling are typically initiated via dimerization of the receptors through homo-oligomeric ligand binding. <br><br>Angiopoietin1 may form homotrimers, but in most cases it assembles into higher-order multimers. This oligomerization is mediated by the N-ter coiled coil domain (CCD). <br>The binding of Ang1 oligomers to Tie2 promotes the dimerization of Tie2, which is further assisted by the interaction between the kinase domains of the receptors.

受体酪氨酸激酶的激活和信号传导通常通过受体通过同源寡聚体配体结合的二聚化而启动。血管生成素1可能形成同源三聚体，但在大多数情况下，它组装成更高阶的多聚体。这种寡聚化过程由N端螺旋卷曲结构域（CCD）介导。Ang1寡聚体与Tie2的结合促进Tie2的二聚化，该过程进一步得到受体激酶域之间相互作用的辅助。