Epigenetic profiling to identify a human effector regulatory T cell core signature [H3K4me1]

We investigated the gene expression profile and active enhancer landscape of human Treg in an autoimmune-associated inflammatory environment, i.e. synovial fluid (SF) from inflamed joints of Juvenile Idiopathic Arthritis (JIA) to improve our understanding of human effector Treg programming. Examination of H3K4me1 modifications in 3 biological replicates of each healthy adult peripheral blood and Juvenile Idiopathic Arthritis patient synovial fluid regulatory T cells.