Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326
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Crystal Structure of Human Beta Secretase in Complex with NVP-AVI326 Descriptor: (2S)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-{[3-(propan-2-yl)benzyl]amino}butan-2-yl]-2-[(5S)-6-oxo-1-propyl-1,7-diazaspiro[4.4]non-7-yl]propanamide, Beta-secretase 1 Authors: Rondeau, J.M, Bourgier, E. Deposit date: 2012-01-09 Release date: 2012-11-21 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
创建时间：
2012-01-09
