ACSL5 Mediates Adaptation to the Palmitic Acid-Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis

Metastasis accounts for 90% of cancer-related death. Distant metastasis follows a non-random pattern, termed “organotropism”, for instance, breast cancer (BC) preferentially metastasizes to the lung, bone, brain, and liver. The lung is a common site for BC metastasis, yet the underlying mechanisms and treatment strategies for lung metastasis remain unclear. To uncover the molecular mechanisms underlying the lung-tropic metastasis of breast tumors, we performed transcriptome sequencing on primary tumors and lung metastases. Overall design: The transcriptome sequencing studies were performed by deep sequencing for HCC1806-LM3, HCC1806-PRI, LT1T2, PT1T2 and PT3 cells.