BindingDB Entry 50047483: Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.

Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, AKT/p21CIP1, ALK tyrosine kinase receptor, Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase, Aurora kinase B/Inner centromere protein, Cyclin-Dependent Kinase 2 (CDK2), Dual specificity protein kinase TTK, Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Inhibitor of NF-kappa-B kinase (IKK), Insulin receptor, Insulin-like growth factor I receptor, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, MAP kinase ERK2, MAP kinase-activated protein kinase 2, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase 14, NT-3 growth factor receptor, Neurotrophic tyrosine kinase receptor, Neurotrophic tyrosine kinase receptor type 2, PKC alpha and beta-2, Pancreatic endoplasmic reticulum kinase (PERK), Platelet-derived growth factor receptor beta, Proto-oncogene tyrosine-protein kinase ROS, SRC, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase EEF2K, Serine/threonine-protein kinase MST4, Serine/threonine-protein kinase NEK6, Serine/threonine-protein kinase NIM1, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK1, Tyrosine kinase non-receptor protein 2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BRK, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase Kit (Kit), Tyrosine-protein kinase SYK, Tyrosine-protein kinase ZAP-70, Tyrosine-protein kinase receptor FLT3, Vascular endothelial growth factor receptor 2, and cAMP-dependent protein kinase (PKA), Uniprot O00311, O00418, O14757, O14920, O14965, O15530, O60674, O96013, P00519, P00533, P04629, P05771, P06213, P06239, P07949, P08069, P08581, P08922, P09619, P10721, P11309, P11362, P17612, P20248, P23458, P24941, P28482, P31749, P33981, P35916, P35968, P36888, P43403, P43405, P49137, P49841, P52333, P53350, Q05397, Q07912, Q13882, Q14680, Q16288, Q16539, Q16620, Q8IY84, Q96GD4, Q9HC98, Q9NZJ5, Q9P289, Q9UBU7, and Q9UM73