Iridium(III)-Catalyzed C–H Amidation of Nitrones with Dioxazolones

Various amidated nitrones were efficiently
achieved through Ir­(III)-catalyzed
direct C–H amidation of nitrones with good to excellent yields
and tolerance of broad functional groups. This reaction smoothly proceeded
at room temperature in the absence of acid or base in a short reaction
time. Carbon dioxide was generated as the sole byproduct, thus providing
an environmentally benign amidation process. The title products could
be efficiently transformed to substituted benzisoxazoline.