LCM-based microarray analysis of TAU-P301L and SOD1-G93A motor neurons and surrounding glial cells

ChEBI2010-07-30 更新2026-07-21 收录

神经退行性分子机制

运动神经元基因表达

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-22482 数据链接链接失效反馈

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资源简介：

LCM-based microarray analysis of TAU-P301L and SOD1-G93A motor neurons and surrounding glial cells

创建时间：

2010-07-30

Profiling common gene expression changes and RBP targets in fly models of the motor neuron degenerative disorders SMA and ALS

运动神经元基因表达

RNA结合蛋白靶标研究

Transcriptome and RNA-binding targets of the fly orthologues of the human disease genes SMN1 (causing Spinal Muscular Atrophy; Dmel SMN), TARDBP and FUS (causing Amyotrophic Lateral Sclerosis; Dmel TB

NIAID Data Ecosystem70

RNA-seq analysis of NSC-34 mouse motor neuron-like cells treated with Negative Control siRNA#1 (siNC#1), siNC#2, Fus siRNA#1 (siFus#1), siFus#4, siFus#5 and siRNA (-) control

神经退行性分子机制

RNA测序基因表达分析

Fused in sarcoma/translated in liposarcoma (FUS) is a causative gene of familial amyotrophic lateral sclerosis (fALS). Mutated FUS causes accumulation of DNA damage and stress granule (SG) formation,

NIAID Data Ecosystem50

Comparative transcriptional profiling of motor neuron disorder-associated genes in various human cell culture models

运动神经元基因表达

细胞模型转录组比较

Disease modelling requires appropriate cellular models that best mimic the underlying pathophysiology. Human origin and an adequate expression of the disease protein are pre-requisites that support in

NIAID Data Ecosystem40

Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by extracellular alpha-synuclein

α-突触核蛋白毒性

神经退行性分子机制

MES cells were treated with vehicle or 250 nM extracellular alpha-synuclein and plasma membrane proteins were labeled with biotin, followed by affinity purification. The biotinylated enriched membrano

NIAID Data Ecosystem60

Aging-Associated Modulation of UFMylation Impairs Proteostasis in C. elegans

衰老相关蛋白

神经退行性分子机制

The attachment of Post-Translational Modifications (PTMs) to proteins plays key roles in the regulation of the activity and stability of various proteins. Here we utilized the nematode Caenorhabditis

NIAID Data Ecosystem40

LCM-based microarray analysis of TAU-P301L and SOD1-G93A motor neurons and surrounding glial cells

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