Glucocorticoid Receptor: MegaTrans Switching Mediates Repression of ERα-Regulated Transcriptional Program [Gro-Seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE81511
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资源简介：
The mechanisms underlying GR-dependent inhibition of ERα-regulated gene activation programs at the global genomic level have been poorly understood. We found the binding of GR in trans on ERα-activated enhancers results in gene and enhancer repression by disassembling the MegaTrans Complex. All GRO-Seq experiments were designed to understand the effects of different ligands (E2, Dex or combine together) treatments to MCF7 cells, to evaluated the two signal cross-talk.
创建时间：
2019-05-15
