The relation between gene expression, clinical variables, and inflammatory markers in the FHS.

1Fold Change for FHS: Total Cholesterol:HDL, BMI, Triglycerides – regression coefficient transformed (2-β) to express fold change in gene expression associated with 1 unit change in clinical covariate, with the exception in BMI (5 points) and triglycerides (50 points). *p<0.05, **p<0.01, ***p<0.001.
2 Fold Change for FHS: CRP and IL6 – regression coefficient transformed (2-β) to express fold change in gene expression associated with loge-CRP or loge-IL6 serum levels adjusted for multiple covariates. *p<0.05, **p<0.01, ***p<0.001.
Abbreviations: BMI – Body mass index, CRP – C-reactive protein, FHS – Framingham Heart Study, HDL – High density lipoprotein, IL6 – Interleukin 6, Total Cholesterol:HDL – Ratio between total and HDL cholesterol, UC – Untreated control.
The relation between gene expression, clinical variables, and inflammatory markers in the FHS.