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Venn diagram depicting the overlap between the differential expressed genes of the three different biofilm collected tooth surfaces (CAa – non-cavitated caries lesions surfaces; CAi – arrested non-cavitated lesions surfaces; CAs – sound tooth surfaces). Fig 3a represents genes up-regulated in CAa related to CAi (blue – 13 genes) and related to CAs (yellow – 19 genes); Fig 3b represents genes up-regulated in CAi related to CAa (blue – 15 genes) and related to CAs (yellow – 21 genes); Fig 3c represent genes up-regulated in CAs related to CAa (blue – 11 genes), related to CAi (yellow – 9 genes). Intersections between blue and yellow diagrams mean common differentially expressed genes between the comparisons.