Microbiome sequencing of ulcerative colitis patients receiving fecal microbiota transplantation

Fecal microbiota transplant is a promising therapy for a variety of conditions, including ulcerative colitis where a third of recipients achieve clinical remission after treatment. Parameters maximizing the effectiveness of the therapy are not yet clear, and it is not known how important the transmission of donor microbes to recipients is. Here we have tested the effects of both antibiotic pretreatment and two modes of maintenance dose delivery, capsules versus enema, in a factorial design with 22 patients.