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Cholesterol-lowering Decreased mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP287823
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In an exploratory human study, RNAseq was performed to quantify immune cells present in prostate cancer. Two patients were examined, and both showed increased CD8+ lymphocytes and M1 macrophages scores following cholesterol-lowering intervention with the combination of ezetimibe and simvastatin. Overall design: Two patients were examined and matched pre-treatment prostate biopsy and post-treatment prostatectomy tissue showed that cholesterol-lowering therapy increased immune infiltration in the tumor
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2021-01-03
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