RB-N phosphorylation promotes BRD4-mediated GPCR signaling hyperactivation and BET inhibitor resistance
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https://www.ncbi.nlm.nih.gov/sra/SRP297153
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资源简介：
The combination of CREB inhibitor and JQ1 could overcome the resistance to BET inhibitors in RB loss prostate cancer. Our study firstly showed that ADRB2-CREB pathway was activated after RB loss and considered as the potential target for the prostate cancer therapy Overall design: To find the candidate genes which are regulated by RB, endogenous RB in PC-3 cells were knocked down by shRNA and cells were collected for RNA-seq after puromycin selection.
创建时间：
2022-01-01
