Maternal Obesity is Associated with Ovarian Inflammation and Up-regulation of Early Growth Response Factor (Egr)-1

Maternal obesity during the pre-implantation period leads to a pro-inflammatory milieu in the ovaries. We conducted a global transcriptomic profiling in ovaries from TEN fed rats during the pre-implantation period. Microarray analysis revealed that obesity lead to increased expression of genes related to inflammation, decreased glucose transporters, and dysregulation of ovarian function-related genes in the ovaries. Our results suggest maternal obesity led to an up-regulation of inflammatory genes and Egr-1 protien expression in peri-implantation ovarian tissue, and a concurrent down-regulation of glucose transporters mRNA and AKT and PI3K protein levels.植入前阶段的母体肥胖可诱导卵巢形成促炎微环境。本研究对植入前阶段经TEN喂养的大鼠卵巢开展了全转录组分析。基因芯片（Microarray）分析结果显示，肥胖可使卵巢内炎症相关基因表达上调、葡萄糖转运蛋白表达水平降低，并引发卵巢功能相关基因表达失调。本研究结果表明，母体肥胖可使植入前后卵巢组织中炎症基因与早期生长应答因子1（Egr-1）的蛋白表达上调，同时伴随葡萄糖转运蛋白mRNA以及AKT、PI3K蛋白水平的下调。