Sudden Cardiac Death Holter Database

An estimated 400,000 Americans, and millions more worldwide, die suddenly each year. These events are most often initiated with a sustained ventricular tachyarrhythmia, including ventricular tachycardia (monomorphic or polymorphic), ventricular flutter, or ventricular fibrillation, with a smaller percentage related to a primary bradyarrhythmia. Sudden cardiac death syndrome may be due to a wide variety of different electrical and mechanical substrates, including acute myocardial infarction, chronic coronary disease with prior myocardial infarction(s), cardiomyopathies, myocarditis, valvular heart disease, right ventricular dysplasia, the long Q-T syndrome (acquired or congenital), Wolff-Parkinson-White pre-excitation, the Brugada syndrome, drug toxicity (e.g., proarrhythmic effects of cardioactive drugs; epinephrine, cocaine, and related stimulants), and so forth. Moreover, some individuals have no demonstrable electrical or mechanical predisposition.据估算，美国每年约有40万人、全球范围内另有数百万人口突发猝死。此类事件大多由持续性室性快速性心律失常（sustained ventricular tachyarrhythmia）引发，包括室性心动过速（ventricular tachycardia，分为单形性或多形性）、心室扑动（ventricular flutter）或心室颤动（ventricular fibrillation）；仅少数病例与原发性缓慢性心律失常（primary bradyarrhythmia）相关。 心源性猝死综合征（Sudden cardiac death syndrome）可由多种不同的电学与力学病理基质引发，包括急性心肌梗死（acute myocardial infarction）、既往合并心肌梗死的慢性冠状动脉疾病、心肌病（cardiomyopathies）、心肌炎（myocarditis）、心脏瓣膜病（valvular heart disease）、右心室发育不良（right ventricular dysplasia）、长QT综合征（long Q-T syndrome，分为获得性或先天性）、沃-帕-怀预激综合征（Wolff-Parkinson-White pre-excitation）、布鲁加达综合征（Brugada syndrome）、药物毒性（例如心血管活性药物的致心律失常作用；肾上腺素、可卡因及相关兴奋剂）等。此外，部分患者无明确的电学或力学易患因素。