Interaction of integrin alphaVbeta3 with Fibrillin

Fibrillins are the main constituents of the extracellular microfibrils that form a template for tropoelastin during elastic fibrillogenesis. Fibrillins polymerize extracellularly as parallel bundles of head-to-tail monomers. The integrin receptor alphaVbeta3 is the major receptor for the fibrillin ligands and influences cell shape and migration, focal complex formation, signaling and ECM deposition.

纤维蛋白为构成弹性纤维原丝的细胞外微纤维的主要成分，并在弹性纤维原丝生成过程中充当模板。纤维蛋白在细胞外以首尾相连的单体平行束的形式聚合成聚合物。整合素受体αVβ3是纤维蛋白配体的主要受体，它影响细胞形态和迁移、焦点复合物形成、信号传导以及细胞外基质沉积。