Mutations in the lacZ gene

This is the raw data representing 6,465 independent lacZ mutations from multiple MutaMouse experiments. We curated lacZ mutations from published studies that were collected using a positive selection assay to identify mutations in lacZ that disrupted β-gal function. These 6,465 independent lacZ mutations cause in 2,732 missense mutations that impair β-gal function. The data were used in a publication on the functional mutational landscape of the lacZ gene.

本数据集收录了来自多个MutaMouse实验的6,465个独立的lacZ突变，这些突变源自公开发表的、采用正向选择实验收集的研究成果，旨在识别干扰β-半乳糖苷酶功能的lacZ突变。其中，6,465个独立突变导致了2,732个错义突变，这些错义突变损害了β-半乳糖苷酶的功能。这些数据被应用于关于lacZ基因功能突变谱的学术论文中。