Data for the article "Identification of genes conferring individual-level variation responsible for metabolic dysfunction-associated steatohepatitis using single-cell eQTL analysis"

Article title: Identification of genes conferring individual-level variation responsible for metabolic dysfunction-associated steatohepatitis using single-cell eQTL analysis

This dataset includes following:

Gene expression matrices per sample obtained from cellranger output

Processed snRNA-seq data with cell-level and sample-level metadata in Seurat v4 format

hdWGCNA results including harmonized module expression (hME) values for each single cell and module information

Expression and covariate matrices used for sc-eQTL analysis

Full summary statistics (including non-significant pairs) of sc-eQTLs (liver-eQTL, MASLD-eQTL, and control-eQTL)

A table of significant liver-eQTLs and ieQTLs with comprehensive annotations

A list of GWAS-colocalizing liver-eQTLs

A list of 601 quartets composed of ieGenes, ieSNPs, interacting cell states, and transcription factors (TFs)

Bulk RNA-seq data newly generated during revision

Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with EFHD1 siRNA

Bulk RNA-seq counts matrix and differentially expressed gene list from hepatic organoids treated with FOXO1-specific inhibitor AS1842856

Bulk RNA-seq counts matrix and differentially expressed gene list from HeG2 treated with FOXO1-specific inhibitor AS1842856