E2 influences the cellular pathways regulated by GH in hypothyroid-orchidectomized rat liver.

The genes differentially-expressed in the livers were identified by DNA microarrays as described under Material and Methods. DAVID was used to identify the hepatic KEEG pathways that were affected by GH in the presence of E2. The table shows pathway name, up- and down-regulated genes, P value, and corrected P value (Benjamini). Abbreviations: carbamoyl-phosphate synthetase-1 (CPS1); argininosuccinate synthase (ASS1); acyl-CoA oxidase 1, palmitoyl (ACOX-1); angiopoietin-like 4 (ANGPTL4); diacylglycerol O-acyltransferase 2 (Dgat2); glutamate dehydrogenase 1 (GLUD1); ornithine carbamoyltransferase (OTC); stearoyl-CoA desaturase (Scd); estrogen sulfotransferase (SULT).