Transcriptomic analyses of normal-appearing CNS white matter from multiple sclerosis donors reveal subtype-specific molecular signatures of disease

The transcriptome of normal-appearing white matter for relapse-remitting multiple sclerosis (MS), primary progressive MS and secondary progressive MS was determined using total RNA-sequencing. We then performed a differential gene analysis comparing the normal-appearing white matter for each clinical subtype of MS with non-MS control tissue Comparative analysis of the transcriptional profiles of normal-appearing white matter obtained from non-MS and MS donors diagnosed with different clinical subtypes of disease (RRMS, SPMS, PPMS)