miRNA profile of single hormone receptor positive breast cancer patients

In the current pilot study we aimed to identify differentially expressed miRNAs in two types of single hormone receptor-positive breast cancer [ER(+)/PgR(-) and ER(-)/PgR(+)] with further distinction into HER2-overexpressing/amplified and HER2-negative tumors in a well-established cohort collected at Medical University of Gdańsk. Owing to the complexity of breast cancer and the essential role of both HER2 and the hormone receptors (ER and PgR) in its biology, we were interested in evaluating the differences in miRNA profiles between the 4 ER/PgR/HER2 phenotypes of single hormone receptor positive primary breast tumors.