Drug development is both increasing in cost whilst decreasing in productivity. There is a general acceptance that the current paradigm of R&D needs to change. One alternative approach is drug repositi
1)PolyPhen2 scores close to 1 are likely to be pathogenic (highlighted in bold). HumDiv-trained Polyphen-2 assumes even mildly deleterious alleles as damaging to evaluate rare alleles potentially invo
CSV file containing summary statistics of proteins in association with incident CAD from logistic regression after adjusting for demographics, fasting status, glycemic status, BMI, and HbA1c.
1Adjusted for multiple comparisons (using false discovery rate)2SNP rs3126085 not in Hardy-Weinberg equilibrium3 X chromosome gene, females only4Risk Allele Score: sum of risk allele counts for each o