Epigenetic profiling of enhancers in primary glioblastoma tissues

Glioblastomas are lethal cancers defined by inevitable disease recurrence after maximal surgical and chemoradiological interventions. To identify possible dependencies in glioblastomas undetected by whole transcriptome sequencing, we examined the enhancer landscape marked by histone 3 lysine 27 acetylation (H3K27ac) in primary glioblastoma specimens through ChIP-seq. ChIP-seq experiments on H3K27ac-enriched DNA elements from primary glioblastoma patient tissues