The total synthesis of natural (+)-hyacinthacine C5 was achieved, which allowed correction of its initially proposed structure, as well as six additional hyacinthacine C-type compounds. These compound
As an extension of our earlier structure/activity investigation of resveratrol (1a) cancer cell growth inhibitory activity compared to the structurally related stilbene combretastatin series (e.g., 2a
Unsaturated malonyl esters underwent Pd-catalyzed intramolecular allylic alkylation to give 4-vinyl-substituted γ-lactones. In contrast to the formerly studied cyclization of malonamides, this reactio
Several toll-like receptors (TLRs) reside inside endosomes of specific immune cellsamong them, aberrant activation of TLR7 and TLR9 is implicated in myriad contexts of autoimmune diseases, making the
