Off-target cleavage analysis of AAVS1-specific Cas9 nucleases
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA834963
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资源简介：
In this study, we show that fully viral gene-deleted adenoviral vector delivery of donors prone to HMEJ and HR, together with matched CRISPR-Cas9 complexes, achieves targeted chromosomal integration of large genetic payloads in human cells. This was exploit for the genetic complementation of defective DMD genes in human muscle progenitor cells.
创建时间：
2022-05-04
