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Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE221092
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Sirt6 acts as a negative regulator of FcεRI signaling cascade in mast cells by suppressing PTPRC transcription. Activation of Sirt6 may therefore represent a promising and novel therapeutic strategy for anaphylaxis. RNA-Seq in WT and KO BMMCs to identify any transcriptional changes caused by Sirt6 deficiency
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2023-03-21
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